SynMICdb

SynMICdb aims to facilitate the study of synonymous mutations in cancer. These mutations alter the nucleotide sequence of the gene and the mRNA, but not the amino acid sequence of the respective protein. Synonymous mutations can change mRNA structure, stability, splicing, translation efficiency or impact cis-regulatory sequences. These mutations can be recurrent and conserved and mirror many aspects of cancer driving mutations.

SynMIC数据库（SynMICdb）旨在推动癌症同义突变领域的相关研究。此类突变可改变基因及信使RNA（mRNA）的核苷酸序列，但不会改变对应蛋白质的氨基酸序列。同义突变能够改变mRNA的结构、稳定性、剪接过程与翻译效率，或对顺式调控序列产生影响。这类突变可兼具复发性与保守性特征，并在诸多方面与癌症驱动突变的特征高度相似。