Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with UDP-2-deoxy-2-fluoro-D-glucose

Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with UDP-2-deoxy-2-fluoro-D-glucose Descriptor: 1,3-PROPANDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Roversi, P, Zitzmann, N, Bayo, Y, Ibba, R. Deposit date: 2022-04-15 Release date: 2022-06-22 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.049 Å) Cite: A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint. Iscience, 26, 2023

本数据集为嗜热毛壳菌（Chaetomium thermophilum）来源的UDP-葡萄糖糖蛋白葡萄糖基转移酶（UDP-Glucose Glycoprotein Glucosyltransferase，UGGT）的催化结构域与UDP-2-脱氧-2-氟-D-葡萄糖（UDP-2-deoxy-2-fluoro-D-glucose）结合形成的复合物。复合物组分信息：1,3-丙二醇（1,3-PROPANDIOL）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、钙离子（CALCIUM ION）等。作者：Roversi P、Zitzmann N、Bayo Y、Ibba R。入库日期：2022-04-15，发布日期：2022-06-22，最后修改日期：2024-11-13。实验方法：X射线衍射（X-RAY DIFFRACTION，2.049 Å）。引用文献：《8-羟基喹啉类亚毫摩尔级UGGT抑制剂——内质网糖蛋白折叠质量质控检查点》，《Iscience》，第26卷，2023年。