Supplementary Material for: Eosinophilic Colitis, an Uncommon Cause of Diarrhea: Case Report and Literature Review

Eosinophilic colitis and hypereosinophilic syndrome with colic involvement are rare diagnosis that are characterized by wide-ranging gastrointestinal symptoms and idiopathic infiltration of eosinophils in the colon. The diagnostic workup is challenging since there are no standardized criteria. We report a case of a man admitted to the hospital with a history of nonbloody chronic diarrhea. The detailed workup demonstrated blood eosinophilia, and the colonic biopsies revealed extensive eosinophilic infiltration. He was treated with steroids with clinical and analytical improvement. Due to relapsing colitis after therapy withdrawal, he was chronically medicated with 10 mg of prednisolone with ultimate symptom control. This case report describes the diagnostic workup and highlights the most important features of this often underdiagnosed entity.

伴结肠受累的嗜酸性粒细胞性结肠炎（Eosinophilic colitis）与嗜酸性粒细胞增多综合征（hypereosinophilic syndrome）均为罕见病症，以广泛的胃肠道症状及结肠特发性嗜酸性粒细胞浸润为核心特征。由于尚无标准化诊断标准，此类病症的诊断工作极具挑战性。本文报告1例因慢性非血性腹泻病史入院的男性患者。经全面诊断评估发现患者外周血嗜酸性粒细胞增多，结肠活检标本可见广泛嗜酸性粒细胞浸润。患者接受糖皮质激素治疗后，临床症状与实验室指标均获改善。但停药后结肠炎复发，遂予10mg泼尼松龙（prednisolone）长期维持治疗，最终症状得到有效控制。本病例报告详细阐述了该类疾病的诊断流程，并着重阐明了这一常被漏诊的病症的关键特征。