SURVEY AND SUMMARY A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter

The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. To date a large number of sequence-specific DNA–protein interactions have been described for the HIV-1 LTR. The aim of this report is to provide a comprehensive, updated listing of these HIV-1 LTR interactions. It is intended as a reference point to facilitate on-going studies characterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replication.

人类免疫缺陷病毒1型（human immunodeficiency virus type 1，HIV-1）的长末端重复序列（long terminal repeat，LTR）是一类经典的模型启动子系统。对结合该区域的细胞蛋白进行鉴定与表征，为真核生物通用转录调控及HIV-1前病毒转录调控机制的研究奠定了基础认知。截至目前，针对HIV-1 LTR已报道了大量序列特异性DNA-蛋白质相互作用事件。本报告旨在全面更新并汇总这些HIV-1 LTR相关相互作用，以期为后续开展HIV-1 LTR结合细胞蛋白的身份鉴定，以及LTR特定区域在HIV-1复制过程中所发挥的功能作用的相关研究提供参考依据。