Evidence of an in vivo transfer of a blaCTX-M14-harboring plasmid under antibiotic pressure, Geneva, Switzerland. In vivo transfer of plasmid under antibiotic pressure

Horizontal transfer of plasmid-mediated antibiotic resistance is frequently observed under antibiotic pressure in vitro, however, in vivo evidence remains rare. We present here evidence of transfer of a blaCTX-M-14 harbouring plasmid from a gut-colonizing E. coli to the hypervirulent K. pneumoniae ST23 in a patient who had received cefuroxime therapy.

质粒介导的抗生素耐药性水平转移（Horizontal transfer of plasmid-mediated antibiotic resistance）在体外抗生素选择压力下常被观测到，但体内相关证据仍较为罕见。本研究报道了1例接受头孢呋辛治疗的患者体内，携带blaCTX-M-14基因的质粒从肠道定植大肠杆菌（Escherichia coli，E. coli）向高毒力肺炎克雷伯菌（Klebsiella pneumoniae，K. pneumoniae）ST23型发生转移的实证。