Estimate of bottleneck sizes for the MELAS mutation from a review of the literature.

p = frequency of mutant mtDNA in the progeny; C.I. = lower and upper limits of confidence interval for π at the 0.95 level; N = estimated size of the bottleneck.

p = 子代中突变型线粒体DNA（mutant mtDNA）的频率；C.I. = 参数π在95%置信水平下的置信区间上下限；N = 遗传瓶颈的估计规模。