seu_obj.h5ad

To explore characteristics that might lead to immunopathology in asymptomatic and moderate COVID-19, we performed scRNA-seq together with single-cell V(D)J sequencing using longitudinal PBMCs from 16 hospitalized COVID-19 patients and three healthy controls (HCs) to identify immunological profiles between distinct immune phenotype and disease severity.

为探究无症状及中型新型冠状病毒肺炎（COVID-19）患者中可能引发免疫病理的相关特征，本研究对16例住院COVID-19患者及3例健康对照（HCs）的纵向采集外周血单个核细胞（PBMCs）开展了单细胞RNA测序（scRNA-seq）与单细胞V(D)J测序，以明确不同免疫表型与疾病严重程度之间的免疫学特征谱。