SCG2-LILRB4 interaction supports MDSCs suppressive function by upregulating IL-6-STAT3 signaling pathway. SCG2-LILRB4 interaction supports MDSCs suppressive function by upregulating IL-6-STAT3 signaling pathway

SCG2 functionally interacts with leukocyte Ig-like receptor subfamily B4 (LILRB4) on monocytic cells. M-MDSCs were isolated from tumor bearing WT, LILRB4+/+ or LILRB4+/+ SCG2-/- mice for RNA-seq. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 replicates from each group. Overall design: RNA-seq profiling of M-MDSCs isolated from tumor bearing WT, LILRB4+/+ or LILRB4+/+ SCG2-/- mice

SCG2可与单核细胞表面的白细胞免疫球蛋白样受体亚家族B4（leukocyte Ig-like receptor subfamily B4，LILRB4）发生功能性相互作用。本研究从荷瘤野生型（wild type，WT）、LILRB4+/+以及LILRB4+/+ SCG2-/-小鼠中分离单核细胞型髓系来源抑制性细胞（monocytic myeloid-derived suppressor cells，M-MDSCs）用于RNA测序（RNA-seq）。随后，我们利用各组3次生物学重复的RNA-seq数据开展基因表达谱分析。实验整体设计：对从荷瘤野生型、LILRB4+/+以及LILRB4+/+ SCG2-/-小鼠中分离得到的M-MDSCs进行RNA-seq测序分析。