NHLBI TOPMed - Centers for Common Disease Genomics (CCDG): The Johns Hopkins University School of Medicine Atrial Fibrillation Genetics Study

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is the primary cause of many hospital admissions, and is associated with significant secondary morbidity by increasing the risk of stroke, heart failure, and all-cause mortality. The incidence of AF is on the rise, and it is projected that by the year 2050 more than 10 million patients will be affected by AF in the United States alone. Anti-arrhythmic medications have limited success in maintaining sinus rhythm, are associated with side effects, and appear ineffective at reducing mortality compared to a strategy of rate control and anticoagulation. Given the significant morbidity associated with this common arrhythmia, surgical and catheter ablation techniques have been developed to treat AF. However, despite the... (for more see dbGaP study page.)

心房颤动（Atrial fibrillation, AF）作为最常见的持续性心律失常，是众多住院治疗的首要病因，可通过升高脑卒中、心力衰竭及全因死亡风险引发严重继发性并发症。AF的发病率呈逐年上升态势，预计到2050年，仅美国就将有超过1000万患者受其影响。抗心律失常药物在维持窦性心律方面疗效有限，且易引发不良反应；与心率控制联合抗凝治疗的策略相比，其在降低死亡率方面效果不佳。鉴于该常见心律失常伴随显著的发病负担，科研人员已开发出外科手术与导管消融术（catheter ablation）用于治疗AF。然而尽管……（更多详情请参见dbGaP研究页面）