Quantitative DIA-based proteomic analysis of lysosomes (Lyso-IP) from VPS35[D620N] Mouse Lung with LRRK2 inhibition

This Zenodo deposit contains a publicly available description of the Dataset: Title: "Quantitative DIA-based proteomic analysis of lysosomes (Lyso-IP) from VPS35[D620N] Mouse Lung with LRRK2 inhibition". Description: Proteomic analysis of lung lysosomes from VPS35[D620N] mice treated in vivo with MLi-2 (100 mg/kg, 2 h). Data acquired on an Orbitrap Exploris 480 and processed using DIA-NN 1.8.1. This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual. This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF). This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset本Zenodo存档包含该数据集的公开说明： 标题：《基于定量数据非依赖采集（Data-Independent Acquisition, DIA）的VPS35[D620N]小鼠肺组织经富亮氨酸重复激酶2（LRRK2）抑制处理后的溶酶体免疫沉淀（Lyso-IP）蛋白质组学分析》 数据集说明：本研究对经MLi-2（100mg/kg，体内给药2小时）处理的VPS35[D620N]突变型小鼠的肺组织溶酶体进行蛋白质组学分析。质谱数据采集于Orbitrap Exploris 480质谱仪，并通过DIA-NN 1.8.1软件完成数据处理。 本数据集通过帕金森病研究协同网络云平台（ASAP CRN Cloud，网址：cloud.parkinsonsroadmap.org）向研究人员开放获取，权限申请流程详见《用户手册》。 本研究由帕金森病研究协同网络（Aligning Science Across Parkinson's Collaborative Research Network, ASAP CRN）通过迈克尔·J·福克斯帕金森病研究基金会（Michael J. Fox Foundation for Parkinson's Research, MJFF）资助。 本Zenodo存档由ASAP CRN云平台工作人员代数据集作者创建，旨在为CRN云平台数据集提供可引用的参考文献。