Biomimetic Synthesis of Lankacidin Antibiotics

We
devised short syntheses of lankacidinol and lankacyclinol that
feature biomimetic Mannich macrocyclization. The modular construction
of the carbon framework of these compounds is amenable to rapid structural
diversification for the development of antibiotic and antitumor agents.

我们开发了兰地酸醇（lankacidinol）与兰环醇（lankacyclinol）的简洁合成路线，该路线以仿生曼尼希大环化反应（biomimetic Mannich macrocyclization）为核心特征。这类化合物的碳骨架采用模块化构建方式，便于快速实现结构多样化，可用于抗生素及抗肿瘤药物的研发。