IBS BAG

The IBS BAG includes teams from IBS (Grenoble) and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study the structure-function relationships of proteins with a focus on human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2586 proposal and can be grouped under the following themes: host-pathogen interaction, new therapeutic targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR) together with other biophysical and biochemical studies and, more recently, the use of AI (AlphaFold) to fully understand the complexity of the biological macromolecular systems under study.

IBS BAG 包含来自格勒诺布尔IBS（IBS）的研究团队，以及来自CEA-Cadarache（CEA-Cadarache，圣保罗勒兹迪朗斯）和IRBA（IRBA，奥尔日河畔布雷蒂尼）的外部合作团队。本团队聚焦蛋白质的结构-功能关系研究，研究重点涵盖人类健康、生物技术及研究方法学领域。绝大多数项目均为MX-2586研究提案的延续，可归类为以下六大研究主题：宿主-病原体互作、新型治疗靶点、基础细胞机制、膜蛋白、生物技术应用以及研究方法学。部分项目采用整合式研究手段，结合X射线晶体学（X-ray crystallography）、冷冻电镜（cryo-EM）、小角X射线散射（SAXS）与核磁共振波谱法（NMR）等生物物理及生物化学研究方法，且近年来引入了人工智能（AI，AlphaFold）技术，以全面解析所研究的生物大分子系统的复杂性。