Transcriptome analysis revealed that ischemic postprocessing improved the expression of inflammatory genes in lung ischemia-reperfusion injury

The actual mechanism of lung protection by I-post-C is unknown. The objective of this study was to explore the protective mechanism and potential molecular regulatory network of I-post-C on lung tissue. Transcriptome analysis was conducted on rat lung tissues from sham, ischemia-reperfusion (IR), and I-post-C groups using mRNA-Seq.

缺血后处理（I-post-C）介导肺脏保护作用的具体机制目前仍不明确。本研究旨在探究I-post-C对肺组织的保护机制及其潜在的分子调控网络。研究采用mRNA测序（mRNA-Seq）技术，对假手术组、缺血再灌注（IR）组及I-post-C组大鼠的肺组织进行了转录组分析。