Complication raw data.

Background
Roux-en-Y gastric bypass（RYGB）surgery delivers an improvement in obesity and obesity-related risks. However, due to the limited operational space in the abdominal cavity of mice, the technical complexity of RYGB surgery and the postoperative complications hinder its mechanism research. The aim was to develop a device that makes it easier to anastomose the esophagus to the jejunum.
Methods
We have invented a simple gastrointestinal anastomosis auxiliary device consisting of a rigid front end and a flexible rear end. Thirty male C57BL6J mice were subjected to RYGB with an auxiliary device. Postoperative recovery and survival status of mice were evaluated using body weight, food intake, body fat, and glucose tolerance.
Results
Based on the RYGB surgical methodology reported in previous literature, the anastomosis device described in this article assists in end-to-end anastomosis of the esophagus and jejunum, which reduces surgical difficulty and time. CT scan results revealed that, following a short - term recovery period after mRYGB surgery, no leakage or stenosis was detected at the anastomotic site in the mice. Moreover, after postoperative recovery, there was no significant difference in food intake, weight and body fat distribution compared with Sham mice, but the glucose tolerance of mRYGB mice was significantly improved.
Conclusions
Our modified RYGB surgical method can effectively avoid the problems of anastomotic leakage and stenosis in mice and improve long-term quality of life.

背景
鲁比尼-Y型胃旁路术（Roux-en-Y gastric bypass，RYGB）可改善肥胖及肥胖相关并发症风险。然而，由于小鼠腹腔操作空间有限，RYGB手术的技术复杂度与术后并发症阻碍了其相关机制研究。本研究旨在开发一款可简化食管-空肠吻合操作的辅助装置。

方法
本研究发明了一款结构简单的胃肠道吻合辅助装置，其包含刚性前端与柔性后端。研究选取30只雄性C57BL6J小鼠，采用该辅助装置开展RYGB手术。通过体重、摄食量、体脂含量与葡萄糖耐量评估小鼠的术后恢复与存活状态。

结果
基于既往文献报道的RYGB手术方法，本文所述的吻合装置可辅助完成食管与空肠的端端吻合，降低了手术难度并缩短手术时长。计算机断层扫描（CT）结果显示，小鼠接受改良RYGB（mRYGB）手术后经短期恢复期，吻合部位未出现渗漏或狭窄情况。此外，术后恢复完成后，小鼠的摄食量、体重与体脂分布与假手术（Sham）组小鼠无显著差异，但改良RYGB小鼠的葡萄糖耐量得到显著改善。

结论
本研究改良的RYGB手术方法可有效规避小鼠术后吻合口渗漏与狭窄问题，并可提升长期生活质量。