Activation of p63 initiates quality control programs in oocytes

Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore, Overall design: For differential expression analysis RNA-Seq experiments of mouse were used containing five different points of time (0h, 1h, 2h30min., 4h, 6h) after irradiation wth 0.5 and 0.2 Gy respectively. 30bp single-end reads of RNA-Seq samples on illumina HiSeq.特异性监视机制对于维持生殖细胞（germ cells）的遗传完整性至关重要，生殖细胞不仅是所有体细胞的来源，亦是下一代生殖细胞的起源。因此，DNA损伤与染色体畸变，实验整体设计：为进行差异表达分析，本研究采用小鼠经0.5 Gy与0.2 Gy分别辐照后的五个不同时间点（0h、1h、2h30min、4h、6h）的RNA测序（RNA-Seq）样本。该样本采用Illumina HiSeq平台完成30bp单端测序读段。