Melanoma multi site metastases

Despite multiple large-scale sequencing studies offering substantial insight into the genomic landscape of cutaneous melanoma, the molecular events surrounding disease progression and the resulting molecular heterogeneity between metastases have not been fully elucidated. We have been applying whole genome and transcriptome sequencing across metastases collected during post mortem as well as to multi-site metastases during treatmentEGA study EGAS00001001348

尽管多项大规模测序研究已对皮肤黑色素瘤（cutaneous melanoma）的基因组图谱获得了较为深入的认知，但围绕疾病进展的分子事件以及转移灶间由此产生的分子异质性，尚未得到完全阐明。本团队针对死后采集的转移灶以及治疗期间获取的多部位转移灶开展了全基因组与转录组测序，相关研究隶属于EGA数据库编号为EGAS00001001348的研究项目。