Histone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq). Mus musculus

We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. Overall design: HDAC3 enriched genomic regions in mouse bone marrow dervied macrophages and H3K9Ac enriched genomic regions in wild-type macrophages and macrophages treated with IL-4 and/or deficient in HDAC3.

本研究报道了小鼠骨髓源巨噬细胞（mouse bone marrow derived macrophages）中富集组蛋白去乙酰化酶3（HDAC3）的基因组区域。此外，本研究还报道了存在或缺失HDAC3、以及经Th2细胞因子白细胞介素4（IL-4）处理的巨噬细胞中，组蛋白3赖氨酸9（H3K9）的基因组乙酰化模式。总体实验设计：包含小鼠骨髓源巨噬细胞中HDAC3富集的基因组区域，以及野生型巨噬细胞、经IL-4处理的巨噬细胞与HDAC3缺陷巨噬细胞中的H3K9乙酰化富集基因组区域。