Pd(0)-Catalyzed Decarboxylative Coupling and Tandem C–H Arylation/Decarboxylation for the Synthesis of Heteroaromatic Biaryls

An effective Pd(0) carbene complex was successfully employed
in the decarboxylative coupling of the heteroaromatic carboxylic acids
(imidazo­[1,2-a]­pyridine and isoxazole) with aryl
halides. For carboxyindoles, either decarboxylative coupling or tandem
C–H arylation and decarboxylation occurred, leading to the
formation of C2-monoarylated indoles.

一种高效的钯(0)卡宾配合物（Pd(0) carbene complex）已成功应用于杂芳族羧酸与芳基卤化物的脱羧偶联反应（decarboxylative coupling）中，其中杂芳族羧酸包括咪唑并[1,2-a]吡啶（imidazo[1,2-a]pyridine）与异恶唑（isoxazole）。针对羧基吲哚（carboxyindoles），反应既可发生脱羧偶联，也可进行串联C-H芳基化与脱羧反应，最终生成C2位单芳基化吲哚（C2-monoarylated indoles）。