Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome.

Compared to the total of 5,767 unique self-peptides eluted from the four BLCL in steady state (uninfected), only 4,112 unique self-peptides were found after MV infection. MV infection thus resulted in a 28.7% decrease in the number of unique peptides derived from self-proteins. The observed decrease was irrespective of the presenting HLA molecule (infected vs uninfected, p = 0.0007).

与从4株稳态（未感染状态）的B淋巴母细胞样细胞系（B Lymphoblastoid Cell Line, BLCL）中洗脱获得的共计5767种独特自身肽段相比，麻疹病毒（Measles Virus, MV）感染后仅检出4112种独特自身肽段。由此可见，麻疹病毒感染使源自自身蛋白的独特肽段数量减少了28.7%。该观测到的数量减少与所呈递的人类白细胞抗原（Human Leukocyte Antigen, HLA）分子无关（感染组与未感染组对比，p=0.0007）