Printer emitted particles (PEPs) exposed rat blood miRNA expression profiling. Printer emitted particles (PEPs) exposed rat blood miRNA expression profiling

Printer emitted particles (PEPs)-induced cardiopulmonary adverse effects and health risks and the underlying mechanisms are unknown. The aim of this study was to perform genome-wide mRNA profiling in rat blood to identify non-invasive blood based biomarkers for medical and occupational surveillance. The rats were exposed to printer emitted particles PEPs (exposed) and high efficiency particulate air (HEPA) filtered air (control). Animals were sacrificed on 1, 5, 9, 13, 17 and 21 days for blood collection. Overall design: Printer emitted particles (PEPs) exposed rat blood miRNA expression profiling

打印机排放颗粒（Printer Emitted Particles, PEPs）诱发的心肺不良效应与健康风险及其潜在作用机制目前尚未明确。本研究旨在通过对大鼠血液开展全基因组mRNA表达谱分析，筛选可用于医学与职业健康监测的非侵入性血液生物标志物。实验中将大鼠暴露于打印机排放颗粒（PEPs）环境（暴露组），并以高效空气过滤器（HEPA）过滤后的空气作为对照环境。分别于暴露后第1、5、9、13、17及21天处死动物以采集血液样本。整体实验设计：打印机排放颗粒（PEPs）暴露大鼠血液的miRNA表达谱分析。