Table_1_Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response.XLSX

Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.

具有抗病毒活性的抗菌肽（Antimicrobial Peptides，AMPs），又称抗病毒肽（Antiviral Peptides，AVPs），已成为当前研究热点，且具备开发为药用抗病毒药物的巨大潜力。抗病毒肽可通过靶向病毒生命周期的不同阶段，展现出极强的病毒抑制能力。昆虫是地球上物种最为丰富的动物类群，几乎栖息于陆地所有生态系统与生境中，同时也是天然抗菌肽的重要资源库。然而，昆虫源抗病毒肽的挖掘、功能研究与药物开发仍处于起步阶段。本综述旨在总结目前已得到验证的昆虫源抗病毒肽，发掘潜在的新型昆虫源抗病毒肽，并探讨其合成与作用的潜在机制，以期为解析昆虫抗病毒免疫机制以及开发基于昆虫源抗病毒肽的抗病毒药物提供研究思路。