Epithelial IL-17R signaling mediates reciprocal control of the gut microbiota constraining Th17 lineage commitment. Mus musculus breed:C57BL6J

Given the link between commensal microbiota and Th17 development, there is intense interest in understanding the role of IL-17 in regulating host defense genes expression in the gut. Towards this we have done multiple RNA sequencing analyses on terminal ileum of WT, IL-17A-/-, IL-17RC-/- and intestinal epithelial specific IL-17RA knockout mice all on C57BL6J backgrounds.

鉴于共生微生物群（commensal microbiota）与Th17细胞发育之间的关联，学界对阐明白介素17（IL-17）在调控肠道宿主防御基因的表达中的作用抱有浓厚兴趣。为此，我们对均携带C57BL/6J背景的野生型（Wild Type，WT）、IL-17A基因敲除（IL-17A-/-）、IL-17RC基因敲除（IL-17RC-/-）以及肠道上皮细胞特异性IL-17RA敲除小鼠的回肠末端组织开展了多组RNA测序分析。