New onset neurologic events in people with COVID-19 infection in three regions in China

Objective: To investigate new-onset neurologic impairments associated with coronavirus disease 2019 (COVID-19).

Methods:  A retrospective multicenter cohort study conducted between 18 January and 20 March 2020 including people with confirmed COVID-19 from 56 hospitals officially designated in three Chinese regions; data were extracted from medical records. New-onset neurologic events as assessed by neurology consultants based on manifestations, clinical examination and investigations, in which critical events included disorders of consciousness, stroke, CNS infection, seizures and status epilepticus.

Results:  We enrolled 917 people with average age 48.7 years and 55% were male. The frequency of new onset critical neurologic events was 3.5% (32/917) overall and 9.4% (30/319) among those with severe or critical COVID-19. These were impaired consciousness (n=25) or/and stroke (n=10). The risk of critical neurologic events was highly associated with age above 60 years and previous hi...

研究目的：探讨2019冠状病毒病（COVID-19）相关的新发神经功能障碍。

研究方法：本研究为回顾性多中心队列研究，于2020年1月18日至3月20日开展，纳入中国三个地区官方指定的56家医院中确诊COVID-19的患者；数据来源于医疗记录。新发神经事件由神经科会诊医师根据临床表现、体格检查及辅助检查评估，其中危重事件包括意识障碍、脑卒中、中枢神经系统感染（CNS infection）、癫痫发作及癫痫持续状态。

研究结果：共纳入917例患者，平均年龄48.7岁，男性占55%。总体新发危重神经事件发生率为3.5%（32/917），在重症或危重症COVID-19患者中为9.4%（30/319）。这些事件包括意识障碍（n=25）和/或脑卒中（n=10）。危重神经事件的风险与年龄超过60岁及既往高...