Fig. 5a

Lung adenocarcinoma H1703 cells were engrafted s.c. in nude mice. 9 days later, tumor-bearing mice were randomized to three groups and treated once with 0.3 mg/kg MICAB1 PDB2G-ADCs, IC-PBD2G or vehicle. Tumor volumes per mouse over time are shown (n=9 per group).

将肺腺癌H1703细胞皮下移植于裸小鼠体内。造模9天后，将荷瘤小鼠随机分为三组，分别以0.3 mg/kg剂量单次给予MICAB1 PDB2G-抗体药物偶联物（Antibody-Drug Conjugates, ADCs）、IC-PBD2G或赋形剂。各组小鼠的肿瘤体积随时间变化情况如图所示（每组n=9）。