The Pediatric Template of Brain Perfusion (PTBP)

Magnetic resonance imaging (MRI) captures the dynamics of brain development with high spatial resolu- tion and with complementary modalities that quantify both brain structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder later in life. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses MRI to quantify cortex (T1), white matter (DTI), resting state functional connectivity (BOLD) and brain perfusion, as measured by Arterial Spin Labeling (ASL), in >100 children 7—17 years of age. The PTBP captures, within normally developing children and across several modalities, the trajectories that demarcate critical turning points in brain maturation. This novel resource allows a more detailed understanding of the structural and functional landmarks that are obtained during normal adolescent brain development. This is currently a pre-publication example of a single subject. More data will be added in the future. The PTBP was supported by Danny JJ Wang's R01MH080892

磁共振成像（Magnetic Resonance Imaging, MRI）具备极高的空间分辨率，可捕捉大脑发育的动态变化，并通过多种互补成像模态量化大脑结构与功能。此类测量可为揭示标志健康大脑成熟的神经模式，或是识别个体日后罹患精神疾病的早期风险提供宝贵见解。儿童脑灌注模板（Pediatric Template of Brain Perfusion, PTBP）是一款免费公开的神经影像资源，将助力学界通过多模态神经影像视角，结合认知与环境相关因素，加速对儿童大脑发育的认知。该模板依托磁共振成像（MRI），对100余名7至17岁儿童的大脑皮层（T1加权成像）、白质（弥散张量成像，DTI）、静息态功能连接（血氧水平依赖，BOLD），以及通过动脉自旋标记（Arterial Spin Labeling, ASL）量化的脑灌注水平进行检测。该模板覆盖多模态成像数据，可捕捉正常发育儿童群体中标志大脑成熟关键转折点的发育轨迹。这款全新的资源可帮助学界更细致地理解正常青少年大脑发育过程中出现的结构与功能发育里程碑。目前该资源仅公开了单受试者的预发表示例，后续将补充更多数据。本儿童脑灌注模板由Danny JJ Wang主持的R01MH080892项目资助。