Constrained principal component analysis loadings for the 7 neonatal clinical factors to explain variance in cortical thickness.

Predictor loadings were computed as correlations between component scores and the set of neonatal clinical variables.C.I. = 95% confidence interval; Pain = number of skin-breaking procedures exposure; Morphine = cumulative daily dose in milligrams adjusted for daily body weight; Ventilation = number of days on mechanical ventilation; Surgery = number of surgeries; Infection = number of culture proven infection; SNAP-II = score for neonatal acute physiology; GA = gestational age.†p-value threshold for significance adjusted for multiple comparisons with a false discovery rate (FDR) correction set at 5%; p-values and confidence intervals were computed by bootstrapping 1000 times.

预测因子载荷量通过主成分得分与新生儿临床变量集的相关系数计算得到。C.I.：95%置信区间（Confidence Interval）；疼痛（Pain）：皮肤破损性操作的暴露次数；吗啡（Morphine）：经每日体重校正的毫克级累计日剂量；机械通气时长（Ventilation）：机械通气总天数；手术次数（Surgery）：手术总次数；感染（Infection）：经培养证实的感染次数；新生儿急性生理学评分（SNAP-II）：新生儿急性生理学评分；胎龄（GA, Gestational Age）。†显著性检验的p值阈值经多重比较校正，假发现率（False Discovery Rate, FDR）校正水准设为5%；p值与置信区间均通过1000次自助抽样法计算得到。