Allen Mouse Brain Atlas

The Allen Mouse Brain Atlas is a genome-scale collection of cellular resolution gene expression profiles using in situ hybridization (ISH). Highly methodical data production methods and comprehensive anatomical coverage via dense, uniformly spaced sampling facilitate data consistency and comparability across &gt;20,000 genes. The use of an inbred mouse strain with minimal animal-to-animal variance allows one to treat the brain essentially as a complex but highly reproducible three-dimensional tissue array. The entire Allen Mouse Brain Atlas dataset and associated tools are available through an unrestricted web-based viewing application (<a href="http://mouse.brain-map.org">http://mouse.brain-map.org</a>). The collection of &gt; 650,000 images have been made available in this Open Data bucket to enable efficient access and analysis of the this dataset.

艾伦小鼠脑图谱是一项基因组尺度的细胞分辨率基因表达谱收集项目，该项目采用了原位杂交（ISH）技术。严谨的数据生产方法和通过密集且均匀分布的采样实现的全套解剖学覆盖，确保了数据在超过20,000个基因层面上的一致性和可比性。使用具有最小个体间差异的近交小鼠品系，使得大脑可以被视为一个复杂但高度可重复的三维组织阵列。艾伦小鼠脑图谱的整个数据集及其相关工具，可通过一个无限制的基于网络的浏览应用程序获取（访问链接：[http://mouse.brain-map.org](http://mouse.brain-map.org)）。在此开放数据存储桶中，已提供超过650,000张图像，以便高效访问和分析该数据集。

搜集汇总

背景与挑战

背景概述

Allen Mouse Brain Atlas是一个全基因组、高分辨率的基因表达图谱，专注于成年小鼠大脑。它提供原位杂交图像数据，具有细胞级分辨率，并包括解剖参考图谱和高级可视化工具（如Brain Explorer® 3-D查看器），用于支持基因表达的空间分析。