Expression data from human squamous cell lung cancer line HARA and highly bone metastatic subline HARA-B4.. Homo sapiens

We investigated the molecular mechanisms for osteolytic bone metastasis by selecting human lung cancer cell line subpopulations with elevated metastatic activity and validating genes that are overexpressed in these cells. A bone-seeking squamous lung cancer cell line (HARA-B4) was established by sequentially injecting parental HARA cells into the left ventricle of male 5-week-old nude mice 4 times. Overall design: The parental line HARA and highly bone-metastatic line HARA-B4 were analized. Total of two samples. No replicates.

本研究通过筛选具有高转移活性的人肺癌细胞系亚群，并验证该类细胞中过表达的基因，探究了溶骨性骨转移（osteolytic bone metastasis）的分子机制。通过将亲本HARA细胞连续4次注射至5周龄雄性裸鼠左心室，成功构建了亲骨性肺鳞癌细胞系（HARA-B4）。实验设计：本研究对亲本细胞系HARA与高骨转移潜能细胞系HARA-B4开展了分析。本次数据集共包含2个样本，无生物学重复。