Rhodium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Dibenzooxasilines via Enantioselective Transmetalation

A rhodium-catalyzed asymmetric synthesis of silicon-stereogenic
dibenzooxasilines has been developed. High enantioselectivities have
been achieved by employing (S,S)-Me-Duphos
as the ligand through “enantioselective transmetalation”.

本研究开发了铑催化的硅中心手性二苯并氧杂硅杂环不对称合成策略。以(S,S)-Me-Duphos为配体，通过"对映选择性转金属化"机制，可获得优异的对映选择性。