Base-Catalyzed Selective Synthesis of 2‑Azabicyclo[3.2.0]hept-2-enes and Sulfonyl Vinyl-Substituted Pyrroles from 3‑Aza-1,5-enynes

A base-catalyzed
selective cycloisomerization of 3-aza-1,5-enynes
is developed. This transformation provides a facile access to highly
functionalized 2-azabicyclo[3.2.0]­hept-2-enes and sulfonyl vinyl-substituted
pyrroles. The chemoselectivity was controlled by the substituent pattern
of the substrates.

本研究开发了一种碱催化的3-氮杂-1,5-烯炔(3-aza-1,5-enynes)选择性环异构化反应。该转化可便捷地获得高度官能化的2-氮杂双环[3.2.0]庚-2-烯与磺酰基乙烯基取代吡咯。其化学选择性由底物的取代基模式所调控。