Expression data from normal B cells and chronic lymphocytic leukemia B cells -- with/without treatment of Wnt3a. Homo sapiens

Wnt pathway is dysregulated in CLL-We characterized Wnt pathway gene expression in normal B and CLL-B cells and identified Wnt targets in normal B and CLL-B cells through this data set. In this dataset, we included normal B cells and CLL-B cells for Wnt pathway gene expression. This leads to the identification of 62 Wnt pathway components which are differnetially expressed between normal and CLl-B cells. We also included normal B cells and CLL-B cells with or without Wnt3a treatment and identified 468 and 676 Wnt regulated genes in normal and CLL B cells, respectively. Overall design: 24 normal B cells and 179 CLL-B cells were used in the Wnt pathway gene expression analysis. Three normal and three CLL samples were included in the identification of Wnt regulated targets

Wnt通路（Wnt pathway）在CLL（慢性淋巴细胞白血病）中存在失调。本研究对正常B细胞与CLL-B细胞的Wnt通路基因表达特征进行了表征，并通过本数据集鉴定了正常B细胞与CLL-B细胞中的Wnt靶基因。本数据集纳入了正常B细胞与CLL-B细胞用于Wnt通路基因表达分析，由此鉴定出62个在正常B细胞与CLL-B细胞间存在差异表达的Wnt通路组分。此外，本数据集还纳入了经Wnt3a处理或未经Wnt3a处理的正常B细胞与CLL-B细胞，分别在正常B细胞与CLL-B细胞中鉴定出468个和676个Wnt调控基因。整体实验设计：本研究共纳入24份正常B细胞样本与179份CLL-B细胞样本用于Wnt通路基因表达分析；另外纳入3份正常B细胞样本与3份CLL样本，用于Wnt调控靶标的鉴定。