Blood cells with trisomy 21 overreact to heat shock stress [ATAC-seq]

Lymphoblastoid cells trisomic for chromosome 21 activate the heat shock response more robustly than disomic cells. Overall design: D21 and T21 lymphoblastoid cells derived from EBV infection of B cells from two brothers were assayed before and after heat shock using ATAC-seq, PRO-seq and scRNA-seq. Heat shock was 42C for 1 hour. This dataset includes the ATAC-seq data.

21号染色体三体的淋巴母细胞相较于二体细胞，可更显著地激活热休克反应（heat shock response）。实验设计：从两名兄弟的B细胞经EB病毒（EBV）感染转化得到的二体21（D21）与三体21（T21）淋巴母细胞，在热休克处理前后，分别采用ATAC-seq、PRO-seq及单细胞RNA测序（scRNA-seq）进行检测。热休克处理条件为42℃持续1小时。本数据集包含ATAC-seq相关数据。