The row data presented in Data of combination effect of atovaquone, mefloquine and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces.

The dataset presented here is related to a previous research article titled “Mitochondrial Complex III in Larval Stage of Echinococcus multilocularis as a Potential Chemotherapeutic Target and in vivo Efficacy of Atovaquone Against Primary Hydatid Cysts”[1]. In this report, data were collected by aerobic and anaerobic culture assay of E. multilocularis protscoleces in the presence of 3 anti-echinococcal drug candidates (atovaquone, mefloquine and 3-bromopropionic acid). The data were analyzed by viability of the protoscoleces between day 0 to day 7 from adding drug candidates. In aerobic condition, all drug candidates gave damage to the protoscoleces as described previously [1, 2, 3, 4]. Mefroquine alone and combination use of atovaquone with mefloquine immediately eliminated the protoscoleces while combination of atovaquone with 3-bromopyruvic acid did not showed clear synergy effect. In anaerobic condition, mefloquine alone and combination of atovaquone with mefloquine eliminated protoscoleces immadiately. 3-bromopyruvic acid showed stronger efficacy than that of aerobic condition. Furthermore, combination of atvaquone with 3-bromopruvic acid eliminated the protoscoleces, indicated synergy effect appeared under only anaerobic condition. The data clarified combination use of these three drug eliminated protoscoleces in both aerobic- and anaerobic conditon, which suggested that these could inhibit Echinococcus multilocularis aerobic and anaerobic respiration pathways in vivo. The data would be useful for the development of new drug dosing method for alveolar echinococosis.

本数据集关联于一篇已发表的研究论文，其标题为《多房棘球绦虫（Echinococcus multilocularis）幼虫期线粒体复合物Ⅲ作为潜在化疗靶点及阿托伐醌（atovaquone）对抗原发性棘球蚴的体内药效》[1]。本报告中，研究人员通过需氧与厌氧培养实验，对暴露于3种抗棘球蚴候选药物（阿托伐醌、甲氟喹（mefloquine）及3-溴丙酸（3-bromopropionic acid））的多房棘球绦虫原头蚴（protoscoleces）进行了数据采集。数据以给药后第0天至第7天的原头蚴存活率为指标开展分析。需氧条件下，所有候选药物均如既往研究[1, 2, 3, 4]所述，对原头蚴造成损伤。单独使用甲氟喹，以及阿托伐醌与甲氟喹联合给药，均可快速清除原头蚴；而阿托伐醌与3-溴丙酮酸（3-bromopyruvic acid）联用未表现出显著协同效应。厌氧条件下，单独使用甲氟喹以及阿托伐醌与甲氟喹联合给药同样可快速清除原头蚴。3-溴丙酮酸的药效较需氧条件下更强。此外，阿托伐醌与3-溴丙酮酸联用可清除原头蚴，表明仅在厌氧条件下二者存在协同效应。本数据集明确了三种药物联合使用可在需氧与厌氧条件下均清除原头蚴，提示上述药物可在体内抑制多房棘球绦虫的需氧及厌氧呼吸通路。本数据集可为泡型棘球蚴病（alveolar echinococcosis）的新型给药方案开发提供参考。