Normative Aging Results in Degradation of Gene Networks in a Zebra Finch Basal Ganglia Nucleus Dedicated to Vocal Behavior

Voice and speech patterns change with normative aging and due to neurodegenerative diseases. The role of the brain in driving these vocal changes is not well understood prompting our current study. Here, we relate changes in aging birdsong across young adult, middle age, and old male zebra finches to mRNA level changes in thousands of interacting genes within a finch song-dedicated basal ganglia brain nucleus. Results will provide insight into pivotal molecular pathways driving age-related changes in vocal dysfunction that can be therapeutically targeted.To cite this work, please cite both the associated paper and this dataset.<br><i>For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to [e-mail]</i><br>

语音和言语模式会随正常衰老以及神经退行性疾病而发生改变。大脑在驱动这些发声变化中的作用尚未得到充分理解，这促使我们开展了当前研究。在此，我们将年轻成年、中年及老年雄性斑胸草雀的衰老鸣唱变化，与草雀中负责鸣唱的基底神经节（basal ganglia）脑核内数千个相互作用基因的mRNA水平变化关联起来。研究结果将为揭示驱动年龄相关发声功能障碍变化的关键分子通路提供见解，这些通路可作为治疗靶点。<br><i>引用本研究时，请同时引用相关论文和本数据集。有关本数据集内容的咨询，请联系README.txt文件中列出的通讯作者（Corresponding Author）。行政类咨询（如移除请求、下载问题等）可发送至[e-mail]</i><br>