Supplementary Material for: Can a Lifestyle Genomics Intervention Motivate Patients to Engage in Greater Physical Activity than a Population-Based Intervention? Results from the NOW Randomized Controlled Trial

Background: Lifestyle genomics (LGx) is a science that explores interactions between genetic variation, lifestyle components such as physical activity (PA), and subsequent health- and performance-related outcomes. The objective of this study was to determine whether an LGx intervention could motivate enhanced engagement in PA to a greater extent than a population-based intervention. Methods: In this pragmatic randomized controlled trial, participants received either the standard, population-based Group Lifestyle BalanceTM (GLB) program intervention or the GLB program in addition to the provision of LGx information and advice (GLB + LGx). Participants (n = 140) completed a 7-day PA recall at baseline, 3, 6, and 12 months. Data from the PA recalls were used to calculate metabolic equivalents (METs), a measure of energy expenditure. Statistical analyses included split plot analyses of covariance and binary logistic regression (generalized linear models). Differences in leisure time PA weekly METs, weekly minutes of moderate + high-intensity PA, and adherence to PA guidelines were compared between groups (GLB and GLB + LGx) across the 4 time points. Results: Weekly METs were significantly higher in the GLB + LGx group (1,114.7 ± 141.9; 95% CI 831.5–1,397.8) compared to the standard GLB group (621.6 ± 141.9 MET/week; 95% CI 338.4–904.8) at the 6-month follow-up (p = 0.01). All other results were non-significant. Conclusions: The provision of an LGx intervention resulted in a greater weekly leisure time PA energy expenditure after the 6-month follow-up. Future research should determine how this could be sustained over the long-term. Clinical Trial Registration: NCT03015012.

背景：生活方式基因组学（Lifestyle genomics, LGx）是一门探究遗传变异、身体活动（physical activity, PA）等生活方式因素与后续健康及运动表现相关结局之间相互作用的学科。本研究旨在探究生活方式基因组学干预相较于基于人群的干预，是否能更有效地提升受试者的身体活动参与度。
方法：本研究为务实型随机对照试验，受试者被随机分配接受标准化基于人群的生活方式平衡小组（Group Lifestyle Balance™, GLB）项目干预，或GLB项目联合生活方式基因组学相关信息与建议（GLB + LGx）干预。共计140名受试者在基线、第3、6及12个月时完成为期7天的身体活动回忆问卷。基于身体活动回忆问卷数据计算代谢当量（metabolic equivalents, METs）——这一能量消耗的衡量指标。统计分析方法包括拆分协方差分析与二元logistic回归（广义线性模型）。对比两组（GLB组与GLB+LGx组）在4个时间点的每周闲暇时间身体活动代谢当量、每周中高强度身体活动时长及身体活动指南依从率差异。
结果：在6个月随访时，GLB+LGx组的每周代谢当量为1114.7±141.9（95%置信区间：831.5~1397.8），显著高于标准GLB组的621.6±141.9 MET/周（95%置信区间：338.4~904.8），差异具有统计学意义（p=0.01）；其余所有结果均无统计学显著性。
结论：生活方式基因组学干预可在6个月随访后提升受试者每周闲暇时间身体活动的能量消耗；未来研究应探究如何长期维持这一干预效果。
临床试验注册号：NCT03015012。