Oral Microbiome Stamp in Alzheimer's Disease

The presented study is the first study focused on oral microbiome compartments in AD patients performed in Kazakhstan and Central Asia. Our findings demonstrate the decrease in the periodontitis-associated bacteria in the AD group, along with the absence of periodontitis and AD relations in our cohort. However, certain taxa and metabolic pathways demonstrated a promising perspective from the point of new biomarkers searching area, which requires further studies.

本研究为哈萨克斯坦及中亚地区首个针对阿尔茨海默病（Alzheimer Disease, AD）患者口腔微生物组分区的相关研究。本研究结果显示，阿尔茨海默病组内与牙周炎相关的细菌丰度有所降低，且本研究队列未观察到牙周炎与阿尔茨海默病存在关联。不过，部分分类群与代谢通路在新型生物标志物的探索领域展现出了颇具潜力的应用前景，相关研究仍有待进一步开展。