Table_3_Correlation Between the Wechsler Adult Intelligence Scale- 3rd Edition Metrics and Brain Structure in Healthy Individuals: A Whole-Brain Magnetic Resonance Imaging Study.xlsx

BackgroundThe Wechsler Adult Intelligence Scale, 3rd edition (WAIS-III) is widely used to evaluate the intelligence quotient (IQ). We aimed to investigate the correlation between the WAIS-III metrics and whole-brain structures using magnetic resonance imaging.
MethodsThe participants were 266 healthy, right-handed individuals (age: 45.6 ± 12.9 years, 98 males and 168 females). IQs were evaluated using the WAIS-III and Japanese Adult Reading Test (JART). Voxel-based morphometry and diffusion tensor imaging were performed to analyze the correlation of the WAIS-III metrics and JART score with the gray matter volume and white matter integrity, respectively.
ResultsThe verbal IQ significantly and positively correlated with the left gyrus rectus and anterior cingulate gyrus, left posterior insula and planum polare, and left superior and middle frontal gyri volumes (p < 0.05, corrected). The verbal comprehension group index significantly and positively correlated with the left superior and middle frontal gyri, left gyrus rectus and anterior cingulate gyrus, and left middle frontal gyrus volumes, while the processing speed group index significantly and positively correlated with the bilateral various regional white matter fractional anisotropy values (p < 0.05, corrected). In contrast, the JART score showed no correlation with any brain structure.
ConclusionThese results suggested the neurostructural bases of the WAIS-III IQs and group indices in the brain of healthy individuals.

背景
韦氏成人智力量表第三版（Wechsler Adult Intelligence Scale, 3rd edition, WAIS-III）被广泛用于评估智商（intelligence quotient, IQ）。本研究旨在借助磁共振成像技术，探究WAIS-III各项指标与全脑结构之间的相关性。
方法
本研究纳入266名健康右利手受试者，年龄为45.6±12.9岁，其中男性98名，女性168名。采用韦氏成人智力量表第三版与日本成人阅读测试（Japanese Adult Reading Test, JART）对受试者智商进行评估。分别采用基于体素的形态测量学（voxel-based morphometry, VBM）和弥散张量成像（diffusion tensor imaging, DTI）技术，分析WAIS-III各项指标及JART得分与灰质体积、白质完整性的相关性。
结果
言语智商与左侧直回、前扣带回、左侧后岛叶、额极平面及左侧额上回、额中回的体积呈显著正相关（校正后p<0.05）。言语理解分量表指数与左侧额上回、额中回、左侧直回及前扣带回、左侧额中回的体积呈显著正相关；加工速度分量表指数与双侧多个脑区的白质各向异性分数值呈显著正相关（校正后p<0.05）。与之相反，JART得分与任何脑结构均无相关性。
结论
本研究结果揭示了健康人群大脑中WAIS-III智商及分量表指数的神经结构基础。