Optimal parameter set.

“Best” parameter set found by our optimization scheme: The Hill coefficients and are unit-less positive real numbers. , , , and are rate constants for splicing and translation in units . The activation and Michaelis constants in units of concentrations are , , , , , and . The maximal transcription and degradation rates , , , , , and have units of concentration per hour. The alternative splicing coefficients , , , and are given in units of the inverse of concentration times hour. As we cannot deduce explicit single cell concentration values from the experimental time traces used here, concentration values are given in arbitrary units ([a.u.]) rather than in some hypothetically defined absolute units.

本优化方案所得的最优参数集：希尔系数（Hill coefficients）为无量纲正实数。、、、与 为剪接与翻译的速率常数，单位为 。以浓度为单位的活化常数与米氏常数（Michaelis constants）为 、、、、、与 。最大转录速率与降解速率 、、、、、与 ，其单位为浓度每小时。可变剪接系数 、、、与 ，其单位为浓度的倒数乘以小时。由于本次所用的实验时间轨迹无法推导出明确的单细胞浓度数值，因此浓度值采用任意单位（[a.u.]）而非假设定义的绝对单位。