Antimicrobial wound dressing films containing essential oils and oleoresins of pepper encapsulated in sodium alginate films

ABSTRACT: Medicated wound dressings are important barriers to avoid contamination and, when they contain antimicrobial additives, can be used as treatment for infected wounds. There are several types of polysaccharide materials that serve as matrices for medicated wound dressings, among them, sodium alginate. For the preparation of the films studied in this paper, sodium alginate was employed in combination with essential oils/oleoresins (EO/OL) of six peppers that are commonly used in cooking. The EO/OL were incorporated at three different concentrations (low, intermediate and high). Most of the films prepared had better dispersion of the EO/OL at the intermediate concentration. All films studied in this research were dissolved in water at different rates. The antibacterial activity of the prepared films showed significant results against Escherichia coli, Staphylococcus aureus and Bacillus cereus, and demonstrated that the films studied may be a new alternative for medicated wound dressings.

摘要：含药伤口敷料是阻隔污染的重要屏障，当其添加抗菌添加剂时，还可用于感染性伤口的治疗。可作为含药伤口敷料基质的多糖类材料种类繁多，其中包括海藻酸钠（sodium alginate）。本研究中受试薄膜的制备以海藻酸钠为基材，复配了六种常用烹饪胡椒的精油/油树脂（EO/OL）。实验设置了低、中、高三种浓度梯度以添加该精油/油树脂，多数制备得到的薄膜在中等浓度梯度下，精油/油树脂的分散效果更佳。本研究中所有受试薄膜在水中的溶解速率均存在差异。所制备薄膜对大肠杆菌（Escherichia coli）、金黄色葡萄球菌（Staphylococcus aureus）及蜡样芽孢杆菌（Bacillus cereus）均表现出显著抗菌活性，证实该受试薄膜有望成为含药伤口敷料的新型备选方案。