ChIP-sequencing for histone modifications in primary human hepatocytes from three individuals heterozygous for the T2D risk haplotype at the SLC16A11 locus

ChIP-sequencing for H3K4me1, H3K4me3, and H3K27ac was performed in primary human hepatocytes from three individuals heterozygous for the T2D risk haplotype at the SLC16A11 locus. The goal was to identify allelic skews in chromatin marks at variants at the SLC16A11 locus. Examination of 3 different histone modifications in 1 primary human cell type obtained from 3 individuals.

针对3名在SLC16A11基因座携带2型糖尿病（Type 2 Diabetes, T2D）风险单倍型的杂合子个体的原代人肝细胞，开展了针对组蛋白H3赖氨酸4单甲基化（H3K4me1）、组蛋白H3赖氨酸4三甲基化（H3K4me3）及组蛋白H3赖氨酸27乙酰化（H3K27ac）的染色质免疫共沉淀测序（ChIP-sequencing）实验。本研究旨在鉴定SLC16A11基因座处遗传变异位点的染色质标记的等位基因偏移现象。本数据集对从3名个体中获取的同一种原代人类细胞类型中的3种不同组蛋白修饰进行了检测分析。