3D cyto- and receptor architectonic map of macaque orbitofrontal area 13a (v1.0)

A multimodal analysis of the macaque prefrontal cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of orbitofrontal area 13a of the macaque monkey brain in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates.

本研究针对猕猴前额叶皮层开展多模态分析，旨在构建整合并协调既往发表图谱间差异的三维图谱。本项目采用定量且可经统计学检验的方法分析猕猴额叶的细胞构筑，并结合体外定量受体放射自显影技术，对14种不同神经递质受体的区域及层状分布模式进行检测。将所识别脑区的边界标注至立体定位空间下的猕猴标准脑模板上。本研究首次提供了立体定位空间下猕猴大脑眶额叶13a区的图谱。该图谱可为非人灵长类动物的功能实验分析提供宝贵的研究资源。