Dataset related to the article "Heart and Gut: Gastrointestinal Complications in Cardiac Surgery and Establishing a New Risk Score"

This record contains raw data related to the article “Heart and Gut: Gastrointestinal Complications in Cardiac Surgery and Establishing a New Risk Score”. Introduction: Gastrointestinal (GI) complications following cardiac surgery, though rare (0.4-3%), exhibit a disproportionately high mortality rate (13-63%). This study aims to investigate independent predictors of GI complications and mortality, proposing a risk classification score for GI complications. Methods: A retrospective case-control study involved 8544 cardiac surgery patients (2005-2019). GI complications, defined as bleeding, ischemia/perforation, occlusion, or pancreatitis, prompted propensity-matching (1:2) with a control group. Multivariable logistic regression assessed independent predictors of a combined post-operative complications endpoint. A risk score for GI complications was created and cross-validated, determining the optimal cutoff for identifying complications. Results: After matching, 162 patients were analyzed; 54 experienced postoperative GI complications (GI group), and 108 did not (Control group). Independent predictors of combined endpoints included GI complications (OR 6.976, CI95% 3.005-16.192), NYHA>2 (OR 2.931, CI95% 1.233–6.972), and pre-operative acute myocardial ischemia (OR 1.958, CI95% 1.015–3.778). The risk score, incorporating mitral valve replacement, sex, coronary disease, diabetes, kidney disease, smoking habit, and cardiac rhythm, demonstrated an area under the ROC curve of 0.829. The optimal cutoff was 0.305, with 69.2% sensitivity and 73.5% specificity. Conclusions: Mortality remains high in patients with GI complications, irrespective of treatment type. The proposed risk score offers a valuable tool for identifying individuals at risk for GI complications, emphasizing the need for vigilant monitoring and timely intervention in this critical subset of post-cardiac surgery patients.本数据集包含与论文《心脏与肠道：心脏外科术后胃肠道并发症及新型风险评分构建》相关的原始数据。 引言： 心脏外科术后胃肠道（GI）并发症虽发病率较低（0.4%~3%），但对应的病死率却高得不成比例，达13%~63%。本研究旨在探究胃肠道并发症及死亡的独立预测因素，并构建针对胃肠道并发症的风险分级评分模型。 方法： 本研究为回顾性病例对照研究，纳入2005年至2019年间的8544名心脏外科手术患者。研究将出血、缺血/穿孔、梗阻或胰腺炎定义为胃肠道并发症，并通过1:2倾向得分匹配法为病例组匹配对照组。采用多变量logistic回归分析术后复合并发症终点的独立预测因素。构建胃肠道并发症风险评分模型并进行交叉验证，确定用于并发症筛查的最佳截断值。 结果： 匹配完成后，共纳入162例患者进行分析，其中54例发生术后胃肠道并发症（并发症组），108例未发生（对照组）。术后复合并发症终点的独立预测因素包括胃肠道并发症（优势比OR=6.976，95%置信区间CI：3.005~16.192）、纽约心脏协会（NYHA）心功能分级>2级（OR=2.931，95%CI：1.233~6.972）以及术前急性心肌缺血（OR=1.958，95%CI：1.015~3.778）。该风险评分纳入了二尖瓣置换术、性别、冠状动脉疾病、糖尿病、肾脏疾病、吸烟史及心律等因素，其受试者工作特征曲线（Receiver Operating Characteristic, ROC）下面积为0.829。最佳截断值为0.305，对应灵敏度为69.2%，特异度为73.5%。 结论： 无论采取何种治疗方式，发生胃肠道并发症的患者病死率仍居高不下。本研究构建的风险评分模型可作为筛查胃肠道并发症高危人群的有效工具，提示需对心脏外科术后这一高危亚组患者加强监护并及时采取干预措施。