Identifying of a novel RUNX1-RARA fusion in variant acute promyelocytic leukemia. Identifying of a novel RUNX1-RARA fusion in variant acute promyelocytic leukemia

Here we report a novel fusion gene, RUNX1-RARA, in acute promyelocytic leukemia (APL). RUNX1-RARA triggers APL genesis by mediating transcriptional repression of target genes, and it can be potently restrained by all-trans retinoic acid treatment. Overall design: Comparative gene expression profiling analysis of RNA-seq data for primary murine hematopoietic cells transduced with either empty vector or RUNX1-RARA.

本研究报道了急性早幼粒细胞白血病（acute promyelocytic leukemia, APL）中的一种新型融合基因RUNX1-RARA。该融合基因通过介导靶基因的转录抑制引发APL发生，且可被全反式维甲酸（all-trans retinoic acid）强效抑制。整体实验设计：对分别转染空载体或RUNX1-RARA的原代小鼠造血细胞的RNA测序（RNA-seq）数据进行比较基因表达谱分析。