Congenital ocular toxoplasmosis in consecutive siblings

ABSTRACT Toxoplasma gondii infection can cause ocular manifestations after acquired and congenital disease. We report two cases of symptomatic congenital toxoplasmosis with ocular involvement in non-twin siblings, with a 2-year interval between pregnancies. Vertical transmission of toxoplasmosis in successive pregnancies, which was once considered impossible, is now found to be plausible even in immunocompetent subjects.

摘要：弓形虫（Toxoplasma gondii）感染可在获得性与先天性感染后引发眼部病症。本研究报告2例伴眼部受累的症状性先天性弓形虫病非孪生同胞病例，两例患儿的母亲妊娠间隔为2年。曾被认为不可能发生的连续妊娠弓形虫垂直传播（vertical transmission），如今已被发现即便在免疫功能正常的个体中也具备可行性。