Regional Differences in Metronidazole Resistance and Increasing Clarithromycin Resistance among Helicobacter pylori Isolates from Japan

The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively. While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).

本研究针对日本两个不同地区的幽门螺杆菌（Helicobacter pylori）抗生素耐药模式进行了评估。总体而言，甲硝唑（metronidazole）与克拉霉素（clarithromycin）的耐药率分别为12.4%和12.9%。尽管克拉霉素耐药率未出现地区差异，但京都地区的甲硝唑耐药率（23.8%）显著高于札幌地区（8.1%）。1996年至1999年间，甲硝唑耐药率未发生明显变化，而克拉霉素耐药率翻倍，从9.1%升至18.7%。