Irinotecan or Fluorouracil Plus Leucovorin in Treating Patients With Previously Treated Metastatic Colorectal Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more tumor cells.
PURPOSE: Phase II trial to compare the effectiveness of either irinotecan or fluorouracil plus leucovorin in treating patients who have metastatic colorectal cancer that has been previously treated with oxaliplatin with or without irinotecan.

研究依据：化疗药物可通过不同机制阻滞肿瘤细胞增殖，使其停止生长或发生凋亡；采用不同药物联合方案可杀灭更多肿瘤细胞。
试验目的：本II期临床试验旨在对比伊立替康（irinotecan）单药方案，与氟尿嘧啶（fluorouracil）联合亚叶酸钙（leucovorin）方案，治疗既往接受过含奥沙利铂（oxaliplatin）联合或不联合伊立替康方案治疗的转移性结直肠癌患者的疗效。