Pedigrees.

a The six-generation pedigree of the BRCA1 G462R family. b The three-generation pedigree of the BRCA1 Y856H family. c The four-generation pedigree of the BRCA1 D1733G family. d The four-generation pedigree of the BRCA1 Q1811K family. e The five-generation pedigree of the BRCA1 V1687G family. Patient ages at the time of cancer occurrence are located to the upper left of each symbol. Symbols coloured blue or purple indicate patients with breast cancer or ovarian cancer, respectively; pink indicates skin cancer, green indicates lung cancer, orange indicates prostate cancer, dark red indicates leukaemia, and grey denotes cancers with an unknown primary site. A diagonal indicates deceased individuals. Numbers inside symbols indicate multiple individuals. Asterisks (*) identify patients whose biopsies were used for iPS cell derivation. Nk = age at the time of cancer not known. (ZIP)

a. 乳腺癌易感基因1（BRCA1）G462R家系的六代系谱图；
b. BRCA1 Y856H家系的三代系谱图；
c. BRCA1 D1733G家系的四代系谱图；
d. BRCA1 Q1811K家系的四代系谱图；
e. BRCA1 V1687G家系的五代系谱图。
患者确诊癌症时的年龄标注于每个符号的左上侧。蓝色与紫色填充符号分别代表罹患乳腺癌与卵巢癌的患者；粉色代表皮肤癌患者，绿色代表肺癌患者，橙色代表前列腺癌患者，深红色代表白血病患者，灰色代表原发部位不明的癌症患者。带有对角线的符号代表已故个体。符号内的数字表示该符号对应家系中的多名个体。星号（*）用于标记其活检组织用于诱导多能干细胞（induced pluripotent stem cell, iPS cell）构建的患者。Nk代表癌症确诊时年龄未知。(ZIP)