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bss1 mutants show increased synchronicity of neuronal activity.

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Figshare2016-03-16 更新2026-04-29 收录
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A) Representative calcium-imaging traces from wildtype aCC neurons in two adjacent segments (i.e. ipsilateral, see inset). B) Results of cross-correlation for the traces from the recording shown in A). The peak of the curve (at 800 ms) shows the lag time which presents the best alignment of both traces. C) Peaks plotted for recording from multiple preparations show the majority (black) peak outside of the region considered to show synchronicity. Those that are considered synchronous (i.e. occur within ≤ 199 ms) are shown in red. D) A calcium-imaging trace from two adjacent aCC neurons in the bss1 background. Coincident peaks are marked with dashed lines. E) Cross-correlation for the traces from the recording shown in D). The peak of the curve (at 0 ms) is indicative of synchronised activity. F) Peaks plotted from multiple bss1 preparations. Synchronised peaks are shown in red and asynchronous in black.

A) 来自两个相邻体节(即同侧,详见插图)的野生型aCC神经元的代表性钙成像轨迹。B) 针对A)中记录的轨迹开展互相关分析得到的结果,曲线峰值位于800 ms处,该峰值对应的滞后时间即为两条轨迹实现最佳对齐的时刻。C) 对多份独立样本的记录结果绘制的峰值分布图显示,绝大多数(黑色标记)峰值处于被判定为不同步的区间内;而滞后时间≤199 ms的同步峰值以红色标记。D) bss1遗传背景下两个相邻aCC神经元的钙成像轨迹,重合峰以虚线标注。E) 针对D)中记录的轨迹开展互相关分析得到的结果,曲线峰值位于0 ms处,表明神经元活动存在同步性。F) 对多份bss1遗传背景样本的记录结果绘制的峰值分布图,其中同步峰值以红色标记,异步峰值以黑色标记。
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2016-03-16
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