Gene Expression Profiling of one melanoma cell line after shRNA-mediated knockdown of JMJD2C or LSD1. Gene Expression Profiling of one melanoma cell line after shRNA-mediated knockdown of JMJD2C or LSD1

We hypothesize that knockdown of the H3K9 demethylases JMJD2C or LSD1 results in decreased proliferation and tumorigenic potential Overall design: Examination of gene expression in one melanoma cell line following knockdown of JMJD2C or LSD1

我们提出以下假说：敲低H3K9去甲基化酶（H3K9 demethylases）JMJD2C或LSD1，会降低细胞的增殖能力与致瘤潜能。实验设计：在一株黑色素瘤细胞系中，分别敲低JMJD2C或LSD1后，对其基因表达情况进行检测。