Regression analysis.

Background
Post-stroke fatigue is a typical complication following stroke. However, existing research primarily focused on its underlying mechanisms, and its impact on rehabilitation outcomes has yet to be uncovered.
Objective
This study aims to explore the impact of post-stroke fatigue on rehabilitation outcomes during hospitalization.
Method
This was a prospective multicenter observational study including 46 stroke patients receiving comprehensive rehabilitation treatment. Patients’ basic information was recorded upon admission and patients’ functional independence was assessed with Functional Independence Measure (FIM) both upon admission and discharge. One week after rehabilitation treatment, fatigue, positivity in daily activity, attention, and memory were assessed. Serum biochemical indicators and levels of C-reactive protein (CRP) were assessed weekly following admission. The pain scores were assessed during the first week of hospitalization to calculate the average. Correlation analysis, linear regression and propensity score matching (PSM) were used to analyze the impact of fatigue on FIM scores at discharge and length of hospital stay.
Result
The proportion of patients with low fatigue was 39.13% and significant improvement was revealed in FIM scores upon admissions and discharge [(50.67±18.61) vs. (75.13±21.04), P<0.05]. Positivity in daily activity, attention, and age are factors that influence post-stroke fatigue. After PSM, low-fatigue group (Fatigue score< 3) showed significant higher motor function independence at discharge [(54.39 ± 15.42) vs. (41.89 ± 14.90), P<0.05] and shorter hospital stay [(28.54±9.13)d vs. (37.32 ± 9.81)d, P<0.05] than high-fatigue group. There was a significant difference (P<0.05) in level of CRP between the first inpatient week and the third week, with declining trend.
Conclusion
Post-stroke fatigue can affect the rehabilitation outcomes regarding motor function independence and length of hospital stay.

背景
脑卒中后疲劳是脑卒中后的典型并发症。然而，现有研究多聚焦于其潜在发病机制，其对康复结局的影响尚未得到阐明。
目的
本研究旨在探讨脑卒中后疲劳对住院期间康复结局的影响。
方法
本研究为一项前瞻性多中心观察性研究，共纳入46例接受综合康复治疗的脑卒中患者。于患者入院时记录其基线信息，并分别于入院时及出院时采用功能独立性评定量表（Functional Independence Measure, FIM）评估患者的功能独立性。于康复治疗1周后，评估患者的疲劳程度、日常活动积极性、注意力及记忆力。于入院后每周检测血清生化指标及C反应蛋白（C-reactive protein, CRP）水平。于住院第一周内评估疼痛评分并计算平均值。采用相关性分析、线性回归及倾向得分匹配（propensity score matching, PSM）分析疲劳对出院时功能独立性评分及住院时长的影响。
结果
低疲劳患者占比为39.13%；患者入院时与出院时的功能独立性评分较基线均有显著改善[(50.67±18.61) vs. (75.13±21.04), P<0.05]。日常活动积极性、注意力及年龄为影响脑卒中后疲劳程度的因素。经倾向得分匹配后，低疲劳组（疲劳评分<3）患者出院时的运动功能独立性评分显著高于高疲劳组[(54.39 ± 15.42) vs. (41.89 ± 14.90), P<0.05]，且住院时长更短[(28.54±9.13)d vs. (37.32 ± 9.81)d, P<0.05]。住院第1周与第3周的C反应蛋白水平存在显著差异（P<0.05），呈下降趋势。
结论
脑卒中后疲劳可对运动功能独立性及住院时长相关的康复结局产生影响。